Infographics
The METEORIC-HF Study: The Effect of Omecamtiv Mecarbil on Exercise Capacity in Chronic Heart Failure with Reduced Ejection Fraction Summary:The METEORIC-HF study investigated whether Omecamtiv Mecarbil, a selective cardiac myosin activator, could improve exercise capacity in patients with HFrEF. Results showed no significant improvement in exercise capacity metrics, indicating that…
PROMPT-HF: Electronic Alerts to Improve Heart Failure Therapy in Outpatient Practice The PROMPT-HF trial tested the effectiveness of electronic medical record (EMR) alerts in improving the prescription of guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF). Results indicated that these alerts significantly increased GDMT prescription rates,…
EMPULSE: Empagliflozin in Patients Hospitalized for Acute Heart Failure EMPULSE assessed the effects of empagliflozin, an SGLT2 inhibitor, on patients hospitalized for acute heart failure (AHF). The study showed that empagliflozin significantly improved clinical outcomes, survival, and quality of life for patients hospitalized with AHF, regardless of baseline physical impairment,…
The DIAMOND Study: Patiromer for the Management of Hyperkalemia in Subjects Receiving RAASi for HFrEF Summary:This study evaluated the role of Patiromer in enabling patients with heart failure with reduced ejection fraction (HFrEF) and hyperkalemia to maintain optimal RAAS inhibitor therapy. The findings suggested that Patiromer allowed patients to stay…
The SODIUM-HF Trial: Study of Dietary Intervention Under 100 MMOL in Heart Failure The SODIUM-HF study aimed to evaluate the effect of a low-sodium diet compared to usual care on outcomes for patients with heart failure (HF), regardless of left ventricular ejection fraction (LVEF). Although the low-sodium diet did not…
2022 AHA/ACC/HFSA Heart Failure Management Guidelines - Value Statements This infographic outlines the economic value statements from the 2022 AHA/ACC/HFSA guidelines for heart failure management, helping to prioritize recommendations based on cost-effectiveness and quality of life impact. It categorizes treatments into high, intermediate, and low economic value, aiding clinicians in…
Stage D (Advanced) Heart Failure This infographic summarizes the 2022 AHA/ACC/HFSA Heart Failure Guidelines for Stage D, or advanced heart failure. It highlights indicators of advanced heart failure, including persistent symptoms despite guideline-directed medical therapy (GDMT), and therapeutic considerations for patients, such as inotropes, mechanical circulatory support (MCS), and transplant.…
Heart Failure & Pregnancy This infographic delves into how heart failure (HF) and pregnancy intersect, with a focus on the risks posed by prepregnancy cardiomyopathy and peripartum cardiomyopathy. Women with persistent left ventricular dysfunction (LVEF <50%) before pregnancy are at heightened risk for serious complications, including further LVEF deterioration, maternal…
The Brockenbrough-Braunwald-Morrow Sign: Understanding LVOT Obstruction in HCM This engaging CardioNerds illustration breaks down the Brockenbrough-Braunwald-Morrow sign, highlighting the hemodynamic dynamics in Hypertrophic Cardiomyopathy (HCM). The artwork uses characters to explain how premature ventricular contractions (PVCs) influence left ventricular outflow tract (LVOT) behavior. Key Highlights: Compensatory Pause After PVC: Prolonged…
Inotropes This infographic provides a detailed breakdown of inotropes, including their mechanisms, clinical applications, and adverse effects. What are Inotropes? Inotropes increase the force of myocardial contraction. Their effects vary depending on which adrenergic receptors they activate: Alpha-1: Vasoconstriction Beta-1: Increases inotropy (contractility) and chronotropy (heart rate) Beta-2: Vasodilation Why…